Dataset Information

Proteome analysis of the murine primary placenta

ABSTRACT: The placenta regulates maternal-fetal communication, and its defect leads to significant pregnancy complications. The maternal and embryonic circulations are primitively connected in early placentation, but the function of the placenta during this developmentally essential period is relatively unknown. We thus performed a comparative proteomic analysis of the placenta before and after primary placentation and found that the metabolism and transport of lipids were characteristically activated in this period. The placental fatty acid (FA) carriers in specific placental compartments were upregulated according to gestational age, and metabolomic analysis also showed that the placental transport of FAs increased in a time-dependent manner. Further analysis of two mutant mice models with embryonic lethality revealed that lipid-related signatures could reflect the functional state of the placenta. Our findings highlight the importance of the nutrient transport function of the primary placenta in the early gestational period and the role of lipids in embryonic development.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Placenta

SUBMITTER: Jeonghun Yeom

LAB HEAD: Kyunggon Kim

PROVIDER: PXD026858 | Pride | 2023-09-06

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	190718_BIJ_Placenta_105_KO1_E01.raw	Raw
	190718_BIJ_Placenta_105_KO1_E02.raw	Raw
	190718_BIJ_Placenta_105_KO2_E01.raw	Raw
	190718_BIJ_Placenta_105_KO2_E02.raw	Raw
	190718_BIJ_Placenta_105_WT1_E01.raw	Raw

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Publications

Lipid signatures reflect the function of the murine primary placentation†.

Lee Jong Geol JG Kim Globinna G Park Seul Gi SG Yon Jung-Min JM Yeom Jeonghun J Song Ha Eun HE Cheong Seung-A SA Lim Joon Seo JS Sung Young Hoon YH Kim Kyunggon K Yoo Hyun Ju HJ Hong Eui-Ju EJ Nam Ki-Hoan KH Seong Je Kyung JK Kim Chong Jai CJ Nam Sang-Yoon SY Baek In-Jeoung IJ

Biology of reproduction 20220301 3

The placenta regulates maternal-fetal communication, and its defect leads to significant pregnancy complications. The maternal and embryonic circulations are primitively connected in early placentation, but the function of the placenta during this developmentally essential period is relatively unknown. We thus performed a comparative proteomic analysis of the placenta before and after primary placentation and found that the metabolism and transport of lipids were characteristically activated in ...[more]

PMID: 34850819

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