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Liquid crystal monomers induce placental development and progesterone release dysregulation through transplacental transportation

ABSTRACT: Embryonic and fetal development can be affected during gestation by exposure to xenobiotics that cross the placenta. Liquid crystal monomers (LCMs) are emerging contaminants commonly found in indoor environments; however, whether they can cross the placenta and affect placental development remains unexplored. Here, we developed an evaluation system that integrates human biomonitoring, uterine perfusion in pregnant rats, and placental cells. We found fourteen out of the fifty-six LCMs that were detected in maternal and cord serum samples from ninety-three healthy pregnant women, at median levels of 13.9 and 18.1 ng/mL, respectively. Subsequent exploration of in utero exposure in rats indicated that aromatic amino acid transporter 1 (SLC16A10) mediated transplacental transportation of the LCMs. Placental cells exposed to LCMs exhibited delayed placental development and reduced progesterone release. These findings showed that SLC16A10-mediated transplacental transportation of LCMs inhibits placental development and progesterone release, highlighting the importance of gestational exposure to emerging contaminants.

INSTRUMENT(S): Bruker Daltonics instrument model

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Placenta

SUBMITTER: Zhipeng Cheng

LAB HEAD: Zhipeng Cheng

PROVIDER: PXD059395 | Pride | 2025-01-21

REPOSITORIES: pride

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