Dataset Information

LPA-TriCEPS crosslinked to human VICs

ABSTRACT: We used ligand-receptor capture mass spectrometry that identified major facilitator superfamily domain containing 5 (MFSD5) as a previously unreported Lp(a) receptor.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Valve Cell, Aortic Valve

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Sasha Singh

LAB HEAD: Elena Aikawa

PROVIDER: PXD026861 | Pride | 2023-12-27

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	DualSystems_010_R264R263_E19.raw	Raw
	DualSystems_010_R264R263_E19.shotgun.mzml	Mzml
	DualSystems_011_R264R263_E19.raw	Raw
	DualSystems_011_R264R263_E19.shotgun.mzml	Mzml
	DualSystems_012_R264R263_E19.raw	Raw

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Publications

Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.

Rogers Maximillian A MA Bartoli-Leonard Francesca F Zheng Kang H KH Small Aeron M AM Chen Hao Yu HY Clift Cassandra L CL Asano Takaharu T Kuraoka Shiori S Blaser Mark C MC Perez Katelyn A KA Natarajan Pradeep P Yeang Calvin C Stroes Erik S G ESG Tsimikas Sotirios S Engert James C JC Thanassoulis George G O'Donnell Christopher J CJ Aikawa Masanori M Singh Sasha A SA Aikawa Elena E

Circulation 20231108 5

<h4>Background</h4>High circulating levels of Lp(a) (lipoprotein[a]) increase the risk of atherosclerosis and calcific aortic valve disease, affecting millions of patients worldwide. Although atherosclerosis is commonly treated with low-density lipoprotein-targeting therapies, these do not reduce Lp(a) or risk of calcific aortic valve disease, which has no available drug therapies. Targeting Lp(a) production and catabolism may provide therapeutic benefit, but little is known about Lp(a) cellular ...[more]

PMID: 37937463

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