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Overexpression of Ndr2 disturbs hippocampal circuitry and function

ABSTRACT: The Ndr (nuclear Dbf2-related) family members are highly conserved serine/threonine protein kinases, which function in many cellular processes extending from cytokinesis to neurite outgrowth. In humans, the NDR2 gene is located in a microduplication hotspot on chromosome 12p that is associated with intellectual disabilities in several individuals. To address a putative contribution of Ndr2 overexpression to such cognitive dysfunctions we generated conditional transgenic mice overexpressing Ndr2 in postmigratory forebrain neurons. Proteomic analysis identifies several interaction partners of transgenic Ndr2 relevant to MF maturation. including the leucin-rich repeat kinase 2 (Lrrk2).

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Thilo Kaehne

LAB HEAD: Prof. Dr. Thilo Kaehne

PROVIDER: PXD026867 | Pride | 2021-07-16

REPOSITORIES: Pride

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			Action	DRS
	17_12_15_Oliver_NDR2_IP_area1.mgf	Mgf
	17_12_15_Oliver_NDR2_IP_area1.raw	Raw
	17_12_15_Oliver_NDR2_IP_area10.mgf	Mgf
	17_12_15_Oliver_NDR2_IP_area10.raw	Raw
	17_12_15_Oliver_NDR2_IP_area11.mgf	Mgf

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Overexpression of Ndr2 disturbs hippocampal circuitry and function

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