Dataset Information

Protein expression profile of miR-33b overexpressing ES-2 cells upon OCM treatment

ABSTRACT: Omentum conditioned medium (OCM) is known to enhance ovarian cancer oncogenesis. In this study, miR-33b exerts tumor suppressive effects on ovarian cancer cells in response to omentum conditioned medium (OCM) treatment. To identify the molecular mechanism and main biological pathways involved in the tumor inhibiting activity by miR-33b in the ovarian cancer metastasis. To achieve this, miR-33b was stably overexpressed in ovarian cancer cell line ES-2, and the protein expression profile of miR-33b overexpressing ES-2 cells upon OCM treatment was determined.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ovarian Surface Epithelial Cell Line, Ovarian Surface Epithelial Cell

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Xueyu WANG

LAB HEAD: Dr CHAN, David Wai

PROVIDER: PXD026901 | Pride | 2022-02-17

REPOSITORIES: Pride

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Publications

Epigenetic Silencing of miR-33b Promotes Peritoneal Metastases of Ovarian Cancer by Modulating the TAK1/FASN/CPT1A/NF-κB Axis.

Wang Xueyu X Yung Mingo M H MMH Sharma Rakesh R Chen Fushun F Poon Ying-Tung YT Lam Wai-Yip WY Li Benjamin B Ngan Hextan Y S HYS Chan Karen K L KKL Chan David W DW

Cancers 20210924 19

Peritoneal metastases are frequently found in high-grade serous carcinoma (HGSOC) patients and are commonly associated with a poor prognosis. The tumor microenvironment (TME) is a complex milieu that plays a critical role in epigenetic alterations driving tumor development and metastatic progression. However, the impact of epigenetic alterations on metastatic ovarian cancer cells in the harsh peritoneal microenvironment remains incompletely understood. Here, we identified that miR-33b is frequen ...[more]

PMID: 34638280

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