Proteomics

Dataset Information

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Human NSCLC sh-QKI-6 A549 cell label-free quantification and LC/MS proteomics analysis


ABSTRACT: Label-Free Quantitation of Differentially Expressed Proteins in Sh-QKI6 and sh-NC

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: haihua zhang  

LAB HEAD: Haihua Zhang

PROVIDER: PXD027013 | Pride | 2022-06-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
9606ST_Homo_sapiens__Human__20352.fasta Fasta
A549_R1_1.raw Raw
A549_R1_2.raw Raw
A549_R1_3.raw Raw
A549_R1_4.raw Raw
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Publications

QKI-6 Suppresses Cell Proliferation, Migration, and EMT in Non-Small Cell Lung Cancer.

Zhang Haihua H   Li Junqiang J   Tian Feng F   Su Xuan X   Wang Xinxin X   Tang Di D   Zhang Lei L   Zhang Tao T   Ni Yunfeng Y  

Frontiers in oncology 20220505


The RNA-binding protein quaking homolog 6 (QKI-6) is a tumor-suppressor gene in several cancers. However, its role in non-small cell lung cancer (NSCLC) is unclear. In this study, we aimed to determine the association between QKI-6 expression and survival and clinicopathological features in patients with NSCLC and identify the related mechanisms. Western blot and immunohistochemistry (IHC) were used to detect QKI-6 expression in NSCLC. The effect of QKI-6 on NSCLC cells was determined by overexp  ...[more]

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