Proteomics

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Plasma proteomic profiling reveals Dampness Heat Diarrhea mechanisms in calves

ABSTRACT: Dampness heat diarrhea (DHD) is the leading cause in calves with diarrhea in traditional Chinese medicine (TCM). However, the methods for detecting DHD diarrhea remain subjective or infective. To address this issue, the calves with dampness heat diarrhea were collected and the plasma proteomic was analyzed using data-independent acquisition (DIA)-mass spectrometry- based proteomics. The analysis revealed a total of 52 differentially expressed proteins that were uniquely altered in the DHD calves’ plasma, compared to the control. Bioinformatics analysis showed that these altered proteins were involved in a wide range of biological processes, such as intestinal immune network for IgA production, purine metabolism and PI3K signaling pathway, which implying their potential roles in DHD.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Blood Plasma

SUBMITTER: Zunxiang Yan  

LAB HEAD: Jianxi Li

PROVIDER: PXD027099 | Pride | 2022-10-14

REPOSITORIES: Pride

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Action DRS
20200404_132500_GDP7036.sne Other
S168DIA-J1.raw Raw
S168DIA-J5.raw Raw
S168DIA-J9.raw Raw
S168DIA-Q1.raw Raw
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Publications

Differential proteomic of plasma provides a new perspective on scientific diagnosis and drug screening for dampness heat diarrhea in calves.

Yan Zunxiang Z   Zhang Kang K   Wang Guibo G   Wang Lei L   Zhang Jingyan J   Qiu Zhengying Z   Guo Zhiting Z   Zhang Kai K   Li Jianxi J  

Frontiers in veterinary science 20220920

Dampness heat diarrhea (DHD) is one of the most common syndromes of calf diarrhea. Its complex etiology and lack of objective diagnostic criteria bring great challenges to the diagnosis and treatment of this disease. This study aims to screen some prospective diagnostic biomarkers or therapeutic targets for calves with DHD by investigating the differential protein profiles of plasma between DHD calves and clinically healthy calves by mass spectrometry-based proteomic. A total of 120 DHD calves a  ...[more]

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