Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
SUBMITTER: Lawrence Schopfer
LAB HEAD: Oksana Lockridge
PROVIDER: PXD027203 | Pride | 2022-02-17
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
20210401__Larry_100_CPO_N2a.msf | Msf | |||
20210401__Larry_100_CPO_N2a.pdf | ||||
20210401__Larry_100_CPO_N2a.raw | Raw | |||
20210401__Larry_1C6_SY_cells.msf | Msf | |||
20210401__Larry_1C6_SY_cells.pdf |
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Journal of proteome research 20210901 10
Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of neurodegenerative disease. The mechanism of neurotoxicity is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organophosphorus pesticides, the most stable being adducts on tyrosine. Rabbit monoclonal 1C6 to diethoxyphosphate-modified tyrosine (depY) was created by single B cell cloning. The amino acid sequence and binding constant ( ...[more]