Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ, Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Richard Johnson
LAB HEAD: David Baker
PROVIDER: PXD027295 | Pride | 2022-04-04
REPOSITORIES: Pride
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VP_2019_0621_RJ_06_f1.raw | Raw | |||
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VP_2019_0621_RJ_08_e1.raw | Raw | |||
VP_2019_0621_RJ_09_e2.raw | Raw | |||
VP_2019_0621_RJ_10_d1.raw | Raw |
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Nature structural & molecular biology 20210913 9
Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenues for controlling cellular behavior, but, so far, no such systems have been described. Here we describe the de novo design of two classes of protein switch that link phosphorylation by tyrosine and serine kinases to protein-protein association. In the first cl ...[more]