Proteomics

Dataset Information

0

Proteomes of chromatin fractions derived from SU-DHL-5 cells


ABSTRACT: SU-DHL-5 cells display limited expression of the SUMO isopeptidase SENP6. In this experiment, the chromatin associated fraction of SU-DHL-5 cells was analysed by mass spectrometry. SU-DHL-5 cells were either stably transfected with an empty vector or with a SENP6 expression construct. Changes in protein levels were compared between these two cell lines in triplicate experiments.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Lymph Node

DISEASE(S): Lymphoma

SUBMITTER: Stefan Müller  

LAB HEAD: Stefan Müller

PROVIDER: PXD027355 | Pride | 2022-02-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20210630_GT_UP_EV_1.raw Raw
20210630_GT_UP_EV_2.raw Raw
20210630_GT_UP_EV_3.raw Raw
20210630_GT_UP_SENP6_1.raw Raw
20210630_GT_UP_SENP6_2.raw Raw
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Publications

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.

Schick Markus M   Zhang Le L   Maurer Sabine S   Maurer Hans Carlo HC   Isaakaidis Konstandina K   Schneider Lara L   Patra Upayan U   Schunck Kathrin K   Rohleder Elena E   Hofstetter Julia J   Baluapuri Apoorva A   Scherger Anna Katharina AK   Slotta-Huspenina Julia J   Hettler Franziska F   Weber Julia J   Engleitner Thomas T   Maresch Roman R   Slawska Jolanta J   Lewis Richard R   Istvanffy Rouzanna R   Habringer Stefan S   Steiger Katja K   Baiker Armin A   Oostendorp Robert A J RAJ   Miething Cornelius C   Lenhof Hans-Peter HP   Bassermann Florian F   Chapuy Björn B   Wirth Matthias M   Wolf Elmar E   Rad Roland R   Müller Stefan S   Keller Ulrich U  

Nature communications 20220112 1


SUMOylation is a post-translational modification of proteins that regulates these proteins' localization, turnover or function. Aberrant SUMOylation is frequently found in cancers but its origin remains elusive. Using a genome-wide transposon mutagenesis screen in a MYC-driven B-cell lymphoma model, we here identify the SUMO isopeptidase (or deconjugase) SENP6 as a tumor suppressor that links unrestricted SUMOylation to tumor development and progression. Notably, SENP6 is recurrently deleted in  ...[more]

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