Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Skeletal Muscle Tissue, Tibialis Anterior
DISEASE(S): Muscular Atrophy,Cachexia
SUBMITTER: Zuo-Fei Yuan
LAB HEAD: Fabio Demontis
PROVIDER: PXD027464 | Pride | 2022-02-22
REPOSITORIES: Pride
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Aging_6m24m_F1.1.pepXML | Pepxml | |||
Aging_6m24m_F1.mzXML | Mzxml | |||
Aging_6m24m_F1.raw | Raw | |||
Aging_6m24m_F10.1.pepXML | Pepxml | |||
Aging_6m24m_F10.mzXML | Mzxml |
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Cell reports 20211101 6
Skeletal muscle atrophy is a debilitating condition that occurs with aging and disease, but the underlying mechanisms are incompletely understood. Previous work determined that common transcriptional changes occur in muscle during atrophy induced by different stimuli. However, whether this holds true at the proteome level remains largely unexplored. Here, we find that, contrary to this earlier model, distinct atrophic stimuli (corticosteroids, cancer cachexia, and aging) induce largely different ...[more]