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Amorphous silica nanoparticle exposures can lead to mitochondrial protein changes

ABSTRACT: Mitochondrial fractions from J774 mouse macrophage/monocyte cells were exposed to amorphous silica nanoforms and mitochondrial protein profiles were examined to gain information on relative toxicities of these nanomaterials on mitochondrial pathways and identify potency determinants, for risk characterization. The applicability of this approach for screening mitochondrial toxicity of nanomaterials was also verified.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Macrophage

SUBMITTER: Sadhna Phanse

LAB HEAD: Dr. Prem Kumarathasan

PROVIDER: PXD027593 | Pride | 2023-03-22

REPOSITORIES: Pride

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			Action	DRS
	LH181024_OT_BM3831-58_15_NH2_15_R1_NOTAG_NODETERGENT_J774-MOUSE.msf	Msf
	LH181024_OT_BM3831-58_15_NH2_15_R1_NOTAG_NODETERGENT_J774-MOUSE.mzXML	Mzxml
	LH181024_OT_BM3832-58_15_NH2_15_R2_NOTAG_NODETERGENT_J774-MOUSE.msf	Msf
	LH181024_OT_BM3832-58_15_NH2_15_R2_NOTAG_NODETERGENT_J774-MOUSE.mzXML	Mzxml
	LH181024_OT_BM3833-58_15_TIO2_R1_NOTAG_NODETERGENT_J774-MOUSE.msf	Msf

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Amorphous silica nanoparticle exposures can lead to mitochondrial protein changes

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