Proteomics

Dataset Information

0

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage


ABSTRACT: Quantification of Spike cleavage across different Sars-Cov2 variants by partial reaction monitoring mass spectrometry

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

DISEASE(S): Covid-19

SUBMITTER: Andrea Fossati  

LAB HEAD: Nevan Krogan

PROVIDER: PXD027641 | Pride | 2022-02-22

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
B117_qx022791.raw Raw
B117_qx022792.raw Raw
B117_qx022793.raw Raw
B1351_qx022834.raw Raw
B1351_qx022835.raw Raw
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Publications


SARS-CoV-2 lineages have diverged into highly prevalent variants termed "variants of concern" (VOCs). Here, we characterized emerging SARS-CoV-2 spike polymorphisms in vitro and in vivo to understand their impact on transmissibility and virus pathogenicity and fitness. We demonstrate that the substitution S:655Y, represented in the gamma and omicron VOCs, enhances viral replication and spike protein cleavage. The S:655Y substitution was transmitted more efficiently than its ancestor S:655H in th  ...[more]

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