Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Pancreatic Ductal Adenocarcinoma
SUBMITTER: Mario Oroshi
LAB HEAD: Felix Meißner
PROVIDER: PXD027877 | Pride | 2022-02-11
REPOSITORIES: Pride
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Nature cancer 20220131 3
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like mesenchymal PDAC, which is driven by allelic imbalance, increased gene dosage and subsequent high expression levels of oncogenic KRAS, shows the most aggressive phenotype and strongest therapy resistance. In the present study, we performed a systematic high-throughput combination drug screen and identified a synergistic inter ...[more]