Proteomics

Dataset Information

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Relative quantitative analysis of mouse lung tissue from bleomycin induced pulmonary lung fibrosis mice model through iTRAQ (isobaric tagging for relative and absolute quantification) quantitative proteomics


ABSTRACT: Purpose: iTRAQ performed for proteomic analysis in BLM induced mice lung tissues. The goals of this study is to compare differentially expressed proteomic in BLM induced IPF mice models and control models to evaluate protocols for optimal high-throughput data analysis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung, Epithelial Cell

DISEASE(S): Wounds And Injuries

SUBMITTER: Jie Yan  

LAB HEAD: Jie Yan

PROVIDER: PXD027900 | Pride | 2022-02-17

REPOSITORIES: Pride

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Publications

TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis.

Chen Huifang H   He Andong A   Li Haoyang H   Chen Honglv H   Xie Huancheng H   Luo Liping L   Huang Yuyi Y   Chen Jiaqian J   Guan Jieying J   He Qiaoling Q   Ma Jianjuan J   Ou Changxing C   Tao Ailin A   Yan Jie J  

Cell death & disease 20211013 10


Alveolar epithelial injury is one of the important pathological changes in idiopathic pulmonary interstitial fibrosis (IPF), but the regulatory mechanism remains unclear. Here, we reported that alveolar epithelial type-II cells (AT II) play important roles in pathological process of pulmonary fibrosis. Through iTRAQ (isobaric tagging for relative and absolute quantification) quantitative proteomics, TSSK4 was identified to be upregulated in bleomycin-induced fibrotic mice model, which was furthe  ...[more]

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