Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Lung, Epithelial Cell
DISEASE(S): Wounds And Injuries
SUBMITTER: Jie Yan
LAB HEAD: Jie Yan
PROVIDER: PXD027900 | Pride | 2022-02-17
REPOSITORIES: Pride
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Chen Huifang H He Andong A Li Haoyang H Chen Honglv H Xie Huancheng H Luo Liping L Huang Yuyi Y Chen Jiaqian J Guan Jieying J He Qiaoling Q Ma Jianjuan J Ou Changxing C Tao Ailin A Yan Jie J
Cell death & disease 20211013 10
Alveolar epithelial injury is one of the important pathological changes in idiopathic pulmonary interstitial fibrosis (IPF), but the regulatory mechanism remains unclear. Here, we reported that alveolar epithelial type-II cells (AT II) play important roles in pathological process of pulmonary fibrosis. Through iTRAQ (isobaric tagging for relative and absolute quantification) quantitative proteomics, TSSK4 was identified to be upregulated in bleomycin-induced fibrotic mice model, which was furthe ...[more]