Dataset Information

Interactome of MSN mutations in leukemic cells

ABSTRACT: Characterization of the protein interactome of Moesin-mutated leukemia-initiating cells GPLM and pGM (as in Ugale et al., 2014).

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hematopoietic Tissue, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: Tommaso De Marchi

LAB HEAD: David Bryder

PROVIDER: PXD028261 | Pride | 2022-05-19

REPOSITORIES: Pride

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Publications

A somatic mutation in moesin drives progression into acute myeloid leukemia.

Yuan Ouyang O Ugale Amol A de Marchi Tommaso T Anthonydhason Vimala V Konturek-Ciesla Anna A Wan Haixia H Eldeeb Mohamed M Drabe Caroline C Jassinskaja Maria M Hansson Jenny J Hidalgo Isabel I Velasco-Hernandez Talia T Cammenga Jörg J Magee Jeffrey A JA Niméus Emma E Bryder David D

Science advances 20220420 16

Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provide insights into the biology of transformation but also reveal novel therapeutic opportunities. However, backtracking these events in transformed human AML samples is challenging, if at all possible. Here, we approached this question using a murine i ...[more]

PMID: 35442741

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			Action	DRS
	20210208.MOUSE.up.sp.CAN.fasta	Fasta
	TDM_P2101_150.raw	Raw
	TDM_P2101_151.raw	Raw
	TDM_P2101_152.raw	Raw
	TDM_P2101_154.raw	Raw