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Effect of POR knockdown on the proteome of HepaRG cells

ABSTRACT: Cytochrome P450 oxidoreductase (POR) is involved in the oxidative metabolism of xenobiotics and endogenous compounds like fatty acid and cholesterol. While effects of diminished Por were extensively studied in mouse models, studies in human models are still missing. We used previously established CRISPR/Cas9-mediated POR knockdown in HepaRG cells as a human hepatic cell model to investigate the effects of POR knockdown on global protein expression levels.

INSTRUMENT(S): 6550 iFunnel Q-TOF LC/MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Cell Culture

SUBMITTER: Thierry Schmidlin

LAB HEAD: Ute Hofmann

PROVIDER: PXD028577 | Pride | 2021-11-04

REPOSITORIES: Pride

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			Action	DRS
	1HepRG_1KO_02.d.zip	Other
	1HepRG_1KO_02_DB_search_psm.csv	Csv
	1HepRG_1KO_02_PSM_ions.csv	Csv
	1HepRG_1KO_02_de_novo_only_peptides.csv	Csv
	1HepRG_1KO_02_de_novo_only_peptides.xml	Xml

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