Dataset Information

Cervical cancer cell line panel immunopeptidomics datasets

ABSTRACT: Our extended analysis of the HLA-presented antigen landscape in cervical cancer cells using an integrative proteogenomics approach identifies, next to tumour-associated antigens and tumour-specific neoantigens, presentation of viral canonical, and alternative reading frame (ARF)-derived HLA-presented sequences, including peptides derived from HPV-E1.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Endocervix, Epithelial Cell

DISEASE(S): Cervix Carcinoma

SUBMITTER: Nicola Ternette

LAB HEAD: Nicola Ternette

PROVIDER: PXD028738 | Pride | 2023-03-11

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	FL704_IPP85_Xu_Hela_MHCI_even.mgf	Mgf
	FL704_IPP85_Xu_Hela_MHCI_even.raw	Raw
	FL704_IPP85_Xu_Hela_MHCI_odd.mgf	Mgf
	FL704_IPP85_Xu_Hela_MHCI_odd.raw	Raw
	FL704b_IPP85_Xu_Hela_MHCI_even.mgf	Mgf

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Publications

Novel canonical and non-canonical viral antigens extend current targets for immunotherapy of HPV-driven cervical cancer.

Peng Xu X Woodhouse Isaac I Hancock Gemma G Parker Robert R Marx Kristina K Müller Julius J Salatino Silvia S Partridge Thomas T Nicastri Annalisa A Liao Hanqing H Kruppa Gary G Hellner Karin K Dorrell Lucy L Ternette Nicola N

iScience 20230202 3

Current immunotherapeutic approaches for human papillomavirus (HPV)-driven cervical cancer target the viral oncogenes E6 and E7. We report viral canonical and alternative reading frame (ARF)-derived sequences presented on cervical tumor cells, including antigens encoded by the conserved viral gene E1. We confirm immunogenicity of the identified viral peptides in HPV-positive women, and women with cervical intraepithelial neoplasia. We observe consistent transcription of the E1, E6, and E7 genes ...[more]

PMID: 36876126

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