Proteomics

Dataset Information

0

Influenza B-derived peptide presentation by HLA-B*07:02, -B*08:01 and -B*35:01

ABSTRACT: Analysis of peptide presentation by Human Leukocyte Antigen (HLA) class I of influenza B infected C1R cells expressing HLA-B*07:02, -B*08:01 or -B*35:01.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

DISEASE(S): Influenza

SUBMITTER: Patricia Illing  

LAB HEAD: Anthony W Purcell

PROVIDER: PXD045000 | Pride | 2024-03-04

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
C1R_B0702_peptides_1_1_0.mzid.gz Mzid
C1R_B0801_peptides_1_1_0.mzid.gz Mzid
C1R_B3501_peptides_1_1_0.mzid.gz Mzid
P1PI20190123_pilling_CIRB8_IBV_rep1_p1.mgf Mgf
P1PI20190123_pilling_CIRB8_IBV_rep1_p1.raw Raw
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Publications

Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8<sup>+</sup> T-cells provide broadly cross-reactive immunity and alleviate disease severity by recognizing conserved epitopes. Despite the IBV burden, only 18 IBV-specific T-cell epitopes restricted by 5 HLAs have been identified currently. A broader array of conserved IBV T-cell epitopes is needed to develop effective cross-reactive T-cell based IBV vaccines. Here we iden  ...[more]

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