Proteomics

Dataset Information

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Cardiac Extracellular Matrix Proteomics of Ang II treated mice.

ABSTRACT: MS analysis of samples from left ventricles of mice treated with Ang II infusion for 2 weeks.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Javier Barallobre-Barreiro  

LAB HEAD: Javier Barallobre-Barreiro

PROVIDER: PXD028887 | Pride | 2021-12-15

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
JBB_CA_Mouse_Hearts_20170215_250min_Gu_01.msf Msf
JBB_CA_Mouse_Hearts_20170215_250min_Gu_01.raw Raw
JBB_CA_Mouse_Hearts_20170215_Gu_02.msf Msf
JBB_CA_Mouse_Hearts_20170215_Gu_02.raw Raw
JBB_CA_Mouse_Hearts_20170215_Gu_03.msf Msf
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Publications

<h4>Background</h4>Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) as one of the most abundant proteases. ADAMTS5 cleaves chondroitin sulfate proteoglycans such as versican. The contribution of ADAMTS5 and its substrate versican to HF is unknown.<h4>Methods</h4>Versican remodeling was assessed in mice lacking th  ...[more]

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