Proteomics

Dataset Information

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Extracellular Matrix Proteomics of Human Heart Failure

ABSTRACT: MS analysis of human cardiac samples from left ventricles of patients undergoing cardiac transplantation due to ischaemic heart failure. Analysis of intracellular protein enriched extracts.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

DISEASE(S): Myocardial Ischemia

SUBMITTER: Javier Barallobre-Barreiro  

LAB HEAD: Javier Barallobre-Barreiro

PROVIDER: PXD028906 | Pride | 2021-12-15

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
JBB_hearts_SDS_fract_TMT_20190122_G10_M.msf Msf
JBB_hearts_SDS_fract_TMT_20190122_G10_M1.raw Raw
JBB_hearts_SDS_fract_TMT_20190122_G10_M2.raw Raw
JBB_hearts_SDS_fract_TMT_20190122_G10_M3.raw Raw
JBB_hearts_SDS_fract_TMT_20190122_G11_M.msf Msf
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Publications

<h4>Background</h4>Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) as one of the most abundant proteases. ADAMTS5 cleaves chondroitin sulfate proteoglycans such as versican. The contribution of ADAMTS5 and its substrate versican to HF is unknown.<h4>Methods</h4>Versican remodeling was assessed in mice lacking th  ...[more]

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