Proteomics

Dataset Information

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A proteomic analysis reveals novel miRNA-200c targets and altered signaling pathways in the field of detoxification


ABSTRACT: MircoRNAs are small RNAs which regulate a pleiotropy of cellular processes and are also involved in tumorigenesis, cancer progression and therapy resistance. We investigated the influence of miRNA-200c on chemoresistance of tumor cells. A proteomic approach identified glutathione S-transferases to be differentially expressed when miR-200c was knocked out and cells were treated with the chemotherapeutic drug doxorubicin.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Jan Bernd Stöckl  

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD029147 | Pride | 2023-03-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20200221_B19_DXR_1.raw Raw
20200221_B19_DXR_2.raw Raw
20200221_B19_DXR_3.raw Raw
20200221_B24_DXR_1.raw Raw
20200221_B24_DXR_2.raw Raw
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Publications


Acquired drug resistance constitutes a serious obstacle to the successful therapy of cancer. In the process of therapy resistance, microRNAs can play important roles. In order to combat resistance formation and to improve the efficacy of chemotherapeutics, the mechanisms of the multifaceted hsa-miR-200c on drug resistance were elucidated. Upon knockout of hsa-miR-200c in breast carcinoma cells, a proteomic approach identified altered expression of glutathione S-transferases (GSTs) when cells wer  ...[more]

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