Dataset Information

HMADS cells secretome identification LC/MS/MS

ABSTRACT: The aim of the project was to identify secreted proteins by human multipotent adipose derived stem cells differentiated into white and brown adipocytes.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Subcutaneous Adipose Tissue

SUBMITTER: Adhideb Ghosh

LAB HEAD: Prof. Dr. Christian Wolfrum

PROVIDER: PXD029335 | Pride | 2021-12-01

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20150826mb_7611_b_002.raw	Raw
	20150826mb_7611_w.raw	Raw
	F223158_20150826mb_7611_w.dat	Other
	F223212_20150826mb_7611_b_002.dat	Other
	checksum.txt	Txt

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Publications

GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1.

Balazova Lucia L Balaz Miroslav M Horvath Carla C Horváth Áron Á Moser Caroline C Kovanicova Zuzana Z Ghosh Adhideb A Ghoshdastider Umesh U Efthymiou Vissarion V Kiehlmann Elke E Sun Wenfei W Dong Hua H Ding Lianggong L Amri Ez-Zoubir EZ Nuutila Pirjo P Virtanen Kirsi A KA Niemi Tarja T Ukropcova Barbara B Ukropec Jozef J Pelczar Pawel P Lamla Thorsten T Hamilton Bradford B Neubauer Heike H Wolfrum Christian C

Nature communications 20211208 1

Activation of thermogenic brown and beige adipocytes is considered as a strategy to improve metabolic control. Here, we identify GPR180 as a receptor regulating brown and beige adipocyte function and whole-body glucose homeostasis, whose expression in humans is associated with improved metabolic control. We demonstrate that GPR180 is not a GPCR but a component of the TGFβ signalling pathway and regulates the activity of the TGFβ receptor complex through SMAD3 phosphorylation. In addition, using ...[more]

PMID: 34880217

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