Proteomics

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Longitudinal Plasma Proteomics Analysis of Acute COVID-19


ABSTRACT: The host response to COVID-19 pathophysiology over the first days of infection remains largely unclear especially the mechanisms in the blood compartment. We report here on a longitudinal proteomic analysis of acute phase COVID-19 patients, for which we used blood plasma and MRM proteomics with internal standards as well as DIA. We measured samples on admission for 49 patients, of which 21 with additional samples on days 2, 4, 7, and 14 after admission. We also measured 30 externally obtained samples from healthy individuals for comparison at baseline.

INSTRUMENT(S): 6495B Triple Quadrupole LC/MS, Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Severe Covid-19

SUBMITTER: Yassene Mohammed  

LAB HEAD: Yassene Mohammed

PROVIDER: PXD029437 | Pride | 2022-02-16

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
15001181972.raw Raw
15001182033.raw Raw
15001182081.raw Raw
15001182147.raw Raw
15001237815.raw Raw
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Publications


The host response to COVID-19 pathophysiology over the first few days of infection remains largely unclear, especially the mechanisms in the blood compartment. We report on a longitudinal proteomic analysis of acute-phase COVID-19 patients, for which we used blood plasma, multiple reaction monitoring with internal standards, and data-independent acquisition. We measured samples on admission for 49 patients, of which 21 had additional samples on days 2, 4, 7, and 14 after admission. We also measu  ...[more]

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