Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Sheng Li
LAB HEAD: Sheng Li
PROVIDER: PXD029542 | Pride | 2022-05-20
REPOSITORIES: Pride
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dta_files_hPrep_to_PRIDE_20211102_182954.xml.gz | Xml | |||
hPrePWT_100000s_A.raw | Raw | |||
hPrePWT_100000s_B.raw | Raw | |||
hPrePWT_10000s_A.raw | Raw |
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Liang Wenguang G WG Wijaya Juwina J Wei Hui H Noble Alex J AJ Mancl Jordan M JM Mo Swansea S Lee David D Lin King John V JV Pan Man M Liu Chang C Koehler Carla M CM Zhao Minglei M Potter Clinton S CS Carragher Bridget B Li Sheng S Tang Wei-Jen WJ
Nature communications 20220405 1
Presequence protease (PreP), a 117 kDa mitochondrial M16C metalloprotease vital for mitochondrial proteostasis, degrades presequence peptides cleaved off from nuclear-encoded proteins and other aggregation-prone peptides, such as amyloid β (Aβ). PreP structures have only been determined in a closed conformation; thus, the mechanisms of substrate binding and selectivity remain elusive. Here, we leverage advanced vitrification techniques to overcome the preferential denaturation of one of two ~55 ...[more]