Proteomics

Dataset Information

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CasID on RRM2 promoter region in neuroblastoma

ABSTRACT: dCas9-guided recruitment of the proximity ligation enzyme BirA* to the promoter region of RRM2 in SKNBE2c neuroblastoma cells.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Neuroblastoma

SUBMITTER: Louis Delhaye  

LAB HEAD: Sven Eyckerman

PROVIDER: PXD029630 | Pride | 2022-08-12

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
B005561_Bp_uPac3_CMB-546_SVEYC-Louis_AP-MS_sgLACZ-1.index Other
B005561_Bp_uPac3_CMB-546_SVEYC-Louis_AP-MS_sgLACZ-1.raw Raw
B005563_Bp_uPac3_CMB-546_SVEYC-Louis_AP-MS_sgLACZ-2.index Other
B005563_Bp_uPac3_CMB-546_SVEYC-Louis_AP-MS_sgLACZ-2.raw Raw
B005565_Bp_uPac3_CMB-546_SVEYC-Louis_AP-MS_sgLACZ-3.index Other
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Publications

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition.

Nunes Carolina C   Depestel Lisa L   Mus Liselot L   Keller Kaylee M KM   Delhaye Louis L   Louwagie Amber A   Rishfi Muhammad M   Whale Alex A   Kara Neesha N   Andrews Simon R SR   Dela Cruz Filemon F   You Daoqi D   Siddiquee Armaan A   Cologna Camila Takeno CT   De Craemer Sam S   Dolman Emmy E   Bartenhagen Christoph C   De Vloed Fanny F   Sanders Ellen E   Eggermont Aline A   Bekaert Sarah-Lee SL   Van Loocke Wouter W   Bek Jan Willem JW   Dewyn Givani G   Loontiens Siebe S   Van Isterdael Gert G   Decaesteker Bieke B   Tilleman Laurentijn L   Van Nieuwerburgh Filip F   Vermeirssen Vanessa V   Van Neste Christophe C   Ghesquiere Bart B   Goossens Steven S   Eyckerman Sven S   De Preter Katleen K   Fischer Matthias M   Houseley Jon J   Molenaar Jan J   De Wilde Bram B   Roberts Stephen S SS   Durinck Kaat K   Speleman Frank F  

Science advances 20220713 28

High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identification of drivers for neuroblastoma development. Using this approach, combined with gene dosage impact on expression and survival, we identified ribonucleotide reductase subunit M2 (RRM2) as a candidate dependency factor further supported by growth inhibition upo  ...[more]

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