Proteomics

Dataset Information

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In-depth proteomic analyses reveal unique subtype-specific signatures in small cell lung cancer (part II: cell media)


ABSTRACT: Small-cell lung cancer (SCLC) represents about 13–15% of all lung cancers and with a five-year survival rate of less than 7%, it remains one of the most lethal forms of malignant diseases. It has a very aggressive course and is characterized by extensive chromosomal rearrangements, high mutation burden, and almost universal inactivation of the tumor suppressor genes TP53 and RB1. Therefore, the vast majority of SCLC patients are diagnosed with extensive-stage disease when surgery is not feasible and the treatment options are mostly limited to cytotoxic chemotherapy (CHT) and radiation. Importantly, targeted therapies for these patients have so far failed, and the success of immunotherapy in non-SCLC (NSCLC) has not been reflected in SCLC. Although SCLC has been formerly considered as a homogeneous disease with a single morphological type, recent advances in SCLC research have led to the development of subtype-specific classifications primarily based on neuroendocrine (NE) features and unique molecular profiles. Here, we investigate the general cell line characteristics on protein level, the relationship between the RNA-based classification and the protein expression profile, and the distinct biological processes specific for each subtype.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture, Lung, Cell Culture

DISEASE(S): Lung Small Cell Carcinoma

SUBMITTER: Nicole Woldmar  

LAB HEAD: Melinda Rezeli

PROVIDER: PXD029821 | Pride | 2022-10-14

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
20191213_SCLC10_sn_DDA_R1.raw Raw
20191213_SCLC10_sn_DDA_R2.raw Raw
20191213_SCLC10_sn_DIA_R1.raw Raw
20191213_SCLC11_sn_DDA_R1.raw Raw
20191213_SCLC11_sn_DDA_R2.raw Raw
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Publications


<h4>Background</h4>Small-cell lung cancer (SCLC) molecular subtypes have been primarily characterized based on the expression pattern of the following key transcription regulators: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P) and YAP1 (SCLC-Y). Here, we investigated the proteomic landscape of these molecular subsets with the aim to identify novel subtype-specific proteins of diagnostic and therapeutic relevance.<h4>Methods</h4>Pellets and cell media of 26 human SCLC cell lines were subjecte  ...[more]

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