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Protective effects of breviscapine on HFHC diet-induced C57 mice

ABSTRACT: The phosphorylomics data of liver tissue of 16-week-old HFHC-induced mice treated with saline or breviscapine for 8 weeks. The mice fed with high fat and high cholesterol were also divided into two groups. The control group was treated with normal saline for 8W, and the drug group was treated with breviscapine for 8W n=3.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Jiao Guo

LAB HEAD: Jiao Guo

PROVIDER: PXD029975 | Pride | 2022-08-12

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	HFHC-16W-Breviscapine-8W-1.raw	Raw
	HFHC-16W-Breviscapine-8W-1_20200527114331.raw	Raw
	HFHC-16W-Breviscapine-8W-2.raw	Raw
	HFHC-16W-Breviscapine-8W-2_20200528053632.raw	Raw
	HFHC-16W-Breviscapine-8W-3.raw	Raw

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Publications

Breviscapine alleviates NASH by inhibiting TGF-β-activated kinase 1-dependent signaling.

Lan Tian T Jiang Shuo S Zhang Jing J Weng Qiqing Q Yu Yang Y Li Haonan H Tian Song S Ding Xin X Hu Sha S Yang Yiqi Y Wang Weixuan W Wang Lexun L Luo Duosheng D Xiao Xue X Piao Shenghua S Zhu Qing Q Rong Xianglu X Guo Jiao J

Hepatology (Baltimore, Md.) 20211219 1

<h4>Background and aims</h4>NAFLD is a key component of metabolic syndrome, ranging from nonalcoholic fatty liver to NASH, and is now becoming the leading cause of cirrhosis and HCC worldwide. However, due to the complex and unclear pathophysiological mechanism, there are no specific approved agents for treating NASH. Breviscapine, a natural flavonoid prescription drug isolated from the traditional Chinese herb Erigeron breviscapus, exhibits a wide range of pharmacological properties, including ...[more]

PMID: 34717002

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Protective effects of breviscapine on HFHC diet-induced C57 mice

Project description:The proteomics data of liver tissue of 16-week-old HFHC-induced mice treated with saline or breviscapine for 8 weeks. The mice fed with high fat and high cholesterol were also divided into two groups. The control group was treated with normal saline for 8W, and the drug group was treated with breviscapine for 8W n=3.

2022-08-12 | PXD029867 | Pride

Expression data from ZBP1-expression and ZBP1 nonexpression breast tumors.

Project description:ZBP1/IMP1 is an mRNA binding protein that post-transcriptionally regulates the expression of a handful mRNAs, implicated in maintaining cell polarity and adhesion. We have previously shown that ZBP1 was able to inhibit proliferation and invasiveness of breast carcinoma cells in vitro. In the current study, we utilized orthotopic breast fat pad xenografts to further investigate the ZBP1-mediated functions in breast tumorigenesis and metastasis in vivo. We used microarrays to identify important gene for breast tumor growth and metastasis in response to ZBP1 expression Total RNA was extracted from breast tumor generated from ZBP1-expression and ZBP1-nonexpression MDA231 cells and used for hybridization on Affymetrix microarrays. We sought to obtain gene expression profiles from the individual tumors and identify what genes are up-regulated or down-regulated in the presence of ZBP1. The microarray experiments and data analysis were performed in 'Gene Company Limited' in Senzheng, China. G-10 and G-13, Tumors generated from MDA231/GFP cells; I-5 and I-6, tumors generated from MDA231/ZBP1-GFP cells.

2014-10-24 | E-GEOD-62638 | biostudies-arrayexpress

miR-1245 induce genomic instability

Project description:This experiment is design to evaluate genomic alteration following stably expression of miR-1245, stably knock down of BRCA2 is setup as a positive control Primary normal breast epithelial cells (NBEC) were collected from the mammoplasty material of a 30-year-old woman at the Department of Plastic Surgery, the First Affiliated Hospital of Sun Yat-sen University (P. R. China), in accordance with rules and regulations concerning ethical issues on research use of human subjects in China, and were cultured in the Keratinocyte serum-free medium (Invitrogen, Carlsbad, CA) supplemented with epithelial growth factor, bovine pituitary extract and antibiotics (120 µg/mL streptomycin and 120 µg/mL penicillin). NBEC were infected with virus produced from retro vector pMSCV-miR1245 or empty pMSCV vector; or pSuper Retro BRCA2 shRNA, or pSuper Retro empty vector. After 2 days infection and 3 days culture, genomic DNA was isolated using the QIAamp DNA Mini Kit (QIAGENE, Valencia, CA). CGH microarray hybridization, data generation and normalization were performed in Shanghai Biochip Corporation.

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Project description:Investigation of whole genome gene expression level changes in MTA1-silencing CNE1 cells, compared to the wild-type CNE1 cell. A double chip study using total RNA recovered from two cell lines, CNE1/MTA1-si cells and CNE1 cells. Each chip measures the expression level of 45,033 genes from human.

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iTRAQ experiment to identify proteins that changed before and after NMT1 was knocked down in both Bel-7402 and Bel-7404 cells

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Expression analysis of Streptomyces avermitilis NRRL8165 delta-aveI mutant

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rrp6l1-2 project

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2014-04-16 | E-GEOD-50486 | biostudies-arrayexpress

Nasopharyngeal carcinoma cell lines (copy number analysis)

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2009-03-04 | E-GEOD-15051 | biostudies-arrayexpress

Expression analysis for nasopharyngeal carcinoma cell lines 5-8F

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2009-12-10 | E-GEOD-15921 | biostudies-arrayexpress

Expression analysis for nasopharyngeal carcinoma cell lines (5-8F and 6-10B)

Project description:High metastatic nasopharyngeal carcinoma cell line 5-8F expression patterns against low metastatic nasopharyngeal carcinoma cell line 6-10B. This study was done to screen genes related with metastasis in NPC. The microarray analyses were done in a same batch. 6-10B cells are cultured and harvested at three different time points.

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