Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 荣 王
LAB HEAD: Rong Wang
PROVIDER: PXD030036 | Pride | 2022-08-12
REPOSITORIES: Pride
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Wang Rong R Wen Piaopiao P Yang Ganglong G Feng Yanyan Y Mi Yuanyuan Y Wang Xiaoying X Zhu Shenglong S Chen Yong Q YQ Chen Yong Q YQ
Cell death & disease 20220719 7
Castration-resistance of prostate cancer is one of the most challenging clinical problems. In the present study, we have performed proteomics and glycomics using LNCaP model. Growth differentiation factor-15 (GDF15) level is increased in androgen receptor (AR) inhibitor-resistant cells and the inhibitory effect of GDF15 on epithelial growth factor receptor (EGFR) pathway is relieved by GDF15 N70 glycosylation. Interference of GDF15 (siRNA or N70Q dominant negative) or EGFR pathway (inhibitor or ...[more]