Proteomics

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Influenza A virus replication in primary human kidney cells reveals regulated cell death as a potential factor for acute kidney injury in influenza

ABSTRACT: Influenza A virus (IAV) infection can cause the lethal acute respiratory distress syndrome of the lung (ARDS). However, AKI is frequently noticed and correlated to an increased mortality. While the causality for influenza-related ARDS is well established, the pathogenesis of influenza-related AKI is incompletely understood. Yet, in post mortem studies of patients infected with H1N1- or H5N6-type IAV, viral antigen was detected in tubular and glomerular cells. Relevantly, receptors for human and avian IAV are present on human kidney cells, viremia was observed and IAV was repeatedly detected by infectivity- and PCR assays in human urine.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney Distal Convoluted Tubule Epithelial Cell, Kidney

DISEASE(S): Influenza

SUBMITTER: Shady Amr  

LAB HEAD: Christian Münch

PROVIDER: PXD030093 | Pride | 2024-05-22

REPOSITORIES: Pride

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Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients.

Koch Benjamin B   Shehata Mahmoud M   Müller-Ruttloff Christin C   Gouda Shady A SA   Wetzstein Nils N   Patyna Sammy S   Scholz Anica A   Schmid Tobias T   Dietrich Ursula U   Münch Christian C   Ziebuhr John J   Geiger Helmut H   Martinez-Sobrido Luis L   Baer Patrick C PC   Mostafa Ahmed A   Pleschka Stephan S  

Frontiers in cellular and infection microbiology 20240325

<h4>Introduction</h4>Influenza A virus (IAV) infection can cause the often-lethal acute respiratory distress syndrome (ARDS) of the lung. Concomitantly, acute kidney injury (AKI) is frequently noticed during IAV infection, correlating with an increased mortality. The aim of this study was to elucidate the interaction of IAV with human kidney cells and, thereby, to assess the mechanisms underlying IAV-mediated AKI.<h4>Methods</h4>To investigate IAV effects on nephron cells we performed infectivit  ...[more]

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