Dataset Information

Human Intestinal biopsy tissue LC-MS

ABSTRACT: This is the first report of proteomic analysis for the identification of novel drug targets based on intestinal biopsy tissue, which is significant to hypotheses for mechanistic investigation that are responsible for non-response to IFX and the development of clinical new pharmaceutical drugs. All 12 UC patients were divided into responders to IFX (UCinfG), non-responders to IFX (UCinfL), severe UC (UCsevere) without IFX treatment history and mild UC (UCmild) without IFX treatment history.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

SUBMITTER: lu liu

LAB HEAD: lu liu

PROVIDER: PXD030121 | Pride | 2022-08-12

REPOSITORIES: Pride

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Publications

Proteomic Analysis of Potential Targets for Non-Response to Infliximab in Patients With Ulcerative Colitis.

Liu Lu L Pu Dan D Wang Dandan D Zhang Muhan M Zhou Chuan C Zhang Zhe Z Feng Baisui B

Frontiers in pharmacology 20220613

<b>Background:</b> Infliximab (IFX) is a potent therapeutic agent used for the treatment of conventional refractory ulcerative colitis (UC). However, the high non-response rate of IFX brings difficulties to clinical applications. In the context of proteomics research, our study of differentially expressed proteins (DEPs) is essential for non-response to IFX in UC patients and provides powerful insights into underlying drug resistance mechanisms. <b>Methods:</b> A total of 12 UC patients were div ...[more]

PMID: 35770079

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			Action	DRS
	WD114LQB1.zip	Other
	WD114LQB1_UCinfG1.raw	Raw
	WD114LQB1_UCinfG2.raw	Raw
	WD114LQB1_UCinfG3.raw	Raw
	WD114LQB1_UCinfL1.raw	Raw