Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung
SUBMITTER: Fraser Johnson
LAB HEAD: William Lockwood
PROVIDER: PXD030294 | Pride | 2022-04-04
REPOSITORIES: pride
Action | DRS | |||
---|---|---|---|---|
TPP_DMSO1_LCS32_PSMs.txt | Txt | |||
TPP_DMSO1_LCS32_PeptideGroups.txt | Txt | |||
TPP_DMSO1_LCS32_Proteins.txt | Txt | |||
TPP_DMSO3_LCS34_PSMs.txt | Txt | |||
TPP_DMSO3_LCS34_ProteinGroups.txt | Txt |
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Cell reports 20220201 6
Phenotype-based screening can identify small molecules that elicit a desired cellular response, but additional approaches are required to characterize their targets and mechanisms of action. Here, we show that a compound termed LCS3, which selectively impairs the growth of human lung adenocarcinoma (LUAD) cells, induces oxidative stress. To identify the target that mediates this effect, we use thermal proteome profiling (TPP) and uncover the disulfide reductases GSR and TXNRD1 as targets. We con ...[more]