Proteomics

Dataset Information

0

PFN4 is required for acrosome biogenesis by regulating autophagy through PI3K/AKT/mTOR pathway


ABSTRACT: We generated Pfn4 knockout mice and showed that male mice are infertile and acrosome biogenesis is impaired from first phase of Development (Golgi-phase). Autophagy participates in acrosome formation and LC-MS data showed proteins related to autophagy, PI3K/AKT signaling and mTOR are enriched in PFN4-/- male mice.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Sperm

DISEASE(S): Male Infertility

SUBMITTER: Marc Sylvester  

LAB HEAD: Hubert Schorle

PROVIDER: PXD030394 | Pride | 2022-08-15

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
191028_P_368_NT_062-073_191030.mzML Mzml
191028_P_368_NT_062-073_191030.mzid.gz Mzid
191028_P_368_NT_062-073_191030.pdResult Other
191028_P_368_NT_062-073_191030.pdResultView Other
191028_P_368_NT_062.raw Raw
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