Dataset Information

Pterosin B treatment protect cells from glutamate-induced cytotoxicity

ABSTRACT: The prevalence of neurodegenerative diseases is rapidly increasing with the aging trend of global populations, severely threatening human health and burdening society. However, to date, there is no effective treatment able to halt the progression or cure the diseases. Here, We aim to develop effective treatments for neurodegenerative diseases from novel sources by evaluating their neuroprotective activity and investigating the working mechanism. Primary screening on glutamate-induced excitotoxicity was assessed by MTT assay. The combination of transcriptomics and proteomics analysis were used to identify the targets of pterosin B. The key pathways were enriched by the Kyoto Encyclopedia of Genes and Genomes (KEGG). The core targets were analyzed by protein-protein interactions network by STRING. The mRNA expressions and protein expressions were evaluated using qPCR and western blot, respectively.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Jordy Evan Sulaiman

LAB HEAD: Henry Lam

PROVIDER: PXD030396 | Pride | 2023-03-01

REPOSITORIES: Pride

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Pterosin sesquiterpenoids from Pteris laeta Wall. ex Ettingsh. protect cells from glutamate excitotoxicity by modulating mitochondrial signals.

Cheng Aifang A Zhang Yan Y Sun Jin J Huang Duli D Sulaiman Jordy Evan JE Huang Xin X Wu Long L Ye Wenkang W Wu Chuanhai C Lam Henry H Shi Yusheng Y Qian Pei-Yuan PY

Journal of ethnopharmacology 20230221

<h4>Ethnopharmacological relevance</h4>The genus Pteris (Pteridaceae) has been used as a traditional herb for a long time. In particular, Pteris laeta Wall. ex Ettingsh. has been widely used in traditional Chinese medicine to treat nervous system diseases and some pterosin sesquiterpenes from Pteris show neuroprotective activity, but their underlying molecular mechanisms remain elusive. Therefore, to investigate the neuroprotective activity and working mechanism of pterosin sesquiterpenes from P ...[more]

PMID: 36822346

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			Action	DRS
	C1.mgf	Mgf
	C1.mzML	Mzml
	C1.pep.xml	Pepxml
	C2.mgf	Mgf
	C2.mzML	Mzml