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Dissection of acetylomic profiles in T cell lymphoma following histone deacetylases inhibition

ABSTRACT: The aim was to dissect molecular changes in histone and non-histone protein acetylation dynamics following the genetic or pharmacological inhibition of HDAC activity in a model of Anaplastic Large Cell Lymphoma (ALCL), a T cell non-Hodgkin lymphoma, predominantly found in children and adolescents.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): T Cell

DISEASE(S): Lymphoma

SUBMITTER: Gabriela Lochmanova

LAB HEAD: Zbynek Zdrahal

PROVIDER: PXD030503 | Pride | 2022-10-14

REPOSITORIES: Pride

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			Action	DRS
	4262_Egger_120min-IS_HCD-OT_3s_CRE1_ac-_2_.msf	Msf
	4262_Egger_120min-IS_HCD-OT_3s_CRE1_ee_ID-_3_.msf	Msf
	4262_Egger_120min-IS_HCD-OT_3s_CRE2_ac.msf	Msf
	4262_Egger_120min-IS_HCD-OT_3s_CRE2_ee_ID.msf	Msf
	4262_Egger_120min-IS_HCD-OT_3s_CRE3_ac.msf	Msf

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Publications

Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma.

Zrimšek Maša M Kuchaříková Hana H Draganić Kristina K Dobrovolná Pavlína P Heiss Spornberger Verena V Winkelmayer Lisa L Hassler Melanie R MR Lochmanová Gabriela G Zdráhal Zbyněk Z Egger Gerda G

Cells 20220802 15

Histone deacetylases (HDACs) target acetylated lysine residues in histone and non-histone proteins. HDACs are implicated in the regulation of genomic stability, cell cycle, cell death and differentiation and thus critically involved in tumorigenesis. Further, HDACs regulate T-cell development and HDAC inhibitors (HDACis) have been approved for clinical use in some T-cell malignancies. Still, the exact targets and mechanisms of HDAC inhibition in cancer are understudied. We isolated tumor cell li ...[more]

PMID: 35954222

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Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

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Adaptive epigenetic changes in histone variants and modifications rescue the fitness of Arabidopsis plants with dysfunctional histone chaperones

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Unraveling epigenetic changes in A. thaliana calli: Impact of HDAC inhibitors

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A quantitative proteomic analysis of in vitro assembled chromatin

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Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1

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