Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Trypanosoma Brucei
DISEASE(S): Sleeping Sickness
SUBMITTER: Manfred Heller
LAB HEAD: Isabel Roditi
PROVIDER: PXD030766 | Pride | 2022-02-17
REPOSITORIES: Pride
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Nature communications 20220201 1
The collective movement of African trypanosomes on semi-solid surfaces, known as social motility, is presumed to be due to migration factors and repellents released by the parasites. Here we show that procyclic (insect midgut) forms acidify their environment as a consequence of glucose metabolism, generating pH gradients by diffusion. Early and late procyclic forms exhibit self-organising properties on agarose plates. While early procyclic forms are repelled by acid and migrate outwards, late pr ...[more]