Dataset Information

Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis -- Validation

ABSTRACT: The pathogenesis of multiple sclerosis (MS) remains to be elucidated. Pediatric-onset MS (POMS) represents the earliest stage of the disease. CSF proteins in POMS may therefore provide causal information. Therefore, the aim of the current study was to analyze CSF proteins in children with an initial CNS acquired demyelinating syndrome (ADS) and to make a comparison between POMS and monophasic ADS (mADS). Patients were selected from two prospective pediatric ADS studies. Liquid chromatography-mass spectrometry was performed in a Dutch discovery cohort (POMS n=28; mADS n=39). Parallel reaction monitoring-mass spectrometry was performed on selected proteins more abundant in POMS with ≥ 8 unique peptides in a combined Dutch and Canadian validation cohort (POMS n=48; mADS n=106).

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

DISEASE(S): Multiple Sclerosis,Pediatric Onset

SUBMITTER: Christoph Stingl

LAB HEAD: Theo M. Luider

PROVIDER: PXD031022 | Pride | 2022-09-30

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	190719OLc1_CG-1895-AIS02--PRM_164.raw	Raw
	190719OLc1_CG-1895-AIS02--PRM_164__F158313_.mzid.gz	Mzid
	190719OLc1_CG-1895-AIS02--PRM_164__F158313_.mzid_190719OLc1_CG-1895-AIS02--PRM_164__F158313_.MGF	Mzid
	190719OLc1_CG-1895-AIS03--PRM_162.raw	Raw
	190719OLc1_CG-1895-AIS03--PRM_162__F158314_.mzid.gz	Mzid

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Publications

Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis and not monophasic demyelinating syndromes in childhood.

Bruijstens Arlette L AL Stingl Christoph C Güzel Coşkun C Stoop Marcel P MP Wong Yu Yi M YYM van Pelt E Daniëlle ED Banwell Brenda L BL Bar-Or Amit A Luider Theo M TM Neuteboom Rinze F RF

Multiple sclerosis (Houndmills, Basingstoke, England) 20220924 1

<h4>Background</h4>Pediatric-onset multiple sclerosis (POMS) represents the earliest stage of disease pathogenesis. Investigating the cerebrospinal fluid (CSF) proteome in POMS may provide novel insights into early MS processes.<h4>Objective</h4>To analyze CSF obtained from children at time of initial central nervous system (CNS) acquired demyelinating syndrome (ADS), to compare CSF proteome of those subsequently ascertained as having POMS versus monophasic acquired demyelinating syndrome (mADS) ...[more]

PMID: 36154753

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