Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung Epithelium
DISEASE(S): Lung Cancer
SUBMITTER: John Koomen
LAB HEAD: Uwe Rix
PROVIDER: PXD031346 | Pride | 2024-04-05
REPOSITORIES: Pride
Items per page: 1 - 5 of 21 |
Cell chemical biology 20231016 2
Multiple tyrosine kinase inhibitors (TKIs) are often developed for the same indication. However, their relative overall efficacy is frequently incompletely understood and they may harbor unrecognized targets that cooperate with the intended target. We compared several ROS1 TKIs for inhibition of ROS1-fusion-positive lung cancer cell viability, ROS1 autophosphorylation and kinase activity, which indicated disproportionately higher cellular potency of one TKI, lorlatinib. Quantitative chemical and ...[more]