Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Peripheral Blood Mononuclear Cell, Splenocyte
SUBMITTER: Madeline Kavanagh
LAB HEAD: Benjamin F. Cravatt
PROVIDER: PXD031384 | Pride | 2023-07-20
REPOSITORIES: Pride
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Nature chemical biology 20220912 12
The Janus tyrosine kinase (JAK) family of non-receptor tyrosine kinases includes four isoforms (JAK1, JAK2, JAK3, and TYK2) and is responsible for signal transduction downstream of diverse cytokine receptors. JAK inhibitors have emerged as important therapies for immun(onc)ological disorders, but their use is limited by undesirable side effects presumed to arise from poor isoform selectivity, a common challenge for inhibitors targeting the ATP-binding pocket of kinases. Here we describe the chem ...[more]