Proteomic analysis of small extracellular vesicles (sEVs) derived from primary keratinocytes cultured in different calcium concentrations, treated with a peanut allergen extract and atopic dermatitis (AD)-relevant cytokines
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ABSTRACT: Epidermal keratinocytes are key for maintenance of the integrity of the epidermis. One of the main drivers of keratinocyte differentiation is the calcium gradient; calcium concentration gradually increases towards the outer layers of the epidermis. Atopic dermatitis (AD) is a disorder associated with a chronic inflammatory state and a compromised epidermal barrier. Keratinocytes secrete lipid-rich small extracellular vesicles (sEVs) that acts as mediators of both local and long-distance signaling.
INSTRUMENT(S): TripleTOF 5600+
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Keratinocyte
DISEASE(S): Atopic Dermatitis,Hypersensitivity Reaction Type I Disease
SUBMITTER: Paulina Czaplewska
LAB HEAD: Paulina Czaplewska
PROVIDER: PXD031729 | Pride | 2022-06-07
REPOSITORIES: Pride
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