Proteomics

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Transcriptional, post-transcriptional, and post-translational mechanisms rewrite the tubulin code during cardiac hypertrophy and failure


ABSTRACT: mouse alpha- and beta- tubulin isoform characterization of hypertrophied hearts after 4 days of phenylephrine (PE) or isoproterenol (Iso) induction

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Benjamin Prosser  

LAB HEAD: Benjamin L. Prosser

PROVIDER: PXD031797 | Pride | 2022-05-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20201126-QPRC-SP-346_Con01.raw Raw
20201126-QPRC-SP-346_Con02.raw Raw
20201126-QPRC-SP-346_Con03.raw Raw
20201126-QPRC-SP-346_Con04.raw Raw
20201126-QPRC-SP-346_Con05.raw Raw
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Publications

Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure.

Phyo Sai Aung SA   Uchida Keita K   Chen Christina Yingxian CY   Caporizzo Matthew A MA   Bedi Kenneth K   Griffin Joanna J   Margulies Kenneth K   Prosser Benjamin L BL  

Frontiers in cell and developmental biology 20220401


A proliferated and post-translationally modified microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the "tubulin code"-the permutations of tubulin isoforms and post-translational modifications-is rewritten upon cardiac stress may provide new targets to modulate cardiac remodeling. Further, while tubulin can autoregulate its own expr  ...[more]

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