Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart
SUBMITTER: Benjamin Prosser
LAB HEAD: Benjamin L. Prosser
PROVIDER: PXD031797 | Pride | 2022-05-20
REPOSITORIES: Pride
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Phyo Sai Aung SA Uchida Keita K Chen Christina Yingxian CY Caporizzo Matthew A MA Bedi Kenneth K Griffin Joanna J Margulies Kenneth K Prosser Benjamin L BL
Frontiers in cell and developmental biology 20220401
A proliferated and post-translationally modified microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the "tubulin code"-the permutations of tubulin isoforms and post-translational modifications-is rewritten upon cardiac stress may provide new targets to modulate cardiac remodeling. Further, while tubulin can autoregulate its own expr ...[more]