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Proteome-wide pulse labeling reveals amyloid-impaired protein degradation in Alzheimer’s disease

ABSTRACT: We here present a large-scale proteome-wide profiling of protein turnover in Alzheimer's disease mice model. We integrated in vivo pulse-SILAC labeling and TMT multiplexing with novel mass spectrometry to precisely measure protein half-lives.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Ka Yang

LAB HEAD: Junmin Peng

PROVIDER: PXD031830 | Pride | 2024-10-28

REPOSITORIES: Pride

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			Action	DRS
	PRIDE_sample_information.xlsx	Xlsx
	mtob1_f001.1.pepXML	Pepxml
	mtob1_f001.raw	Raw
	mtob1_f002.1.pepXML	Pepxml
	mtob1_f002.raw	Raw

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