Proteomics

Dataset Information

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DUSP1/6-mediated phosphorylation signaling events in CLL

ABSTRACT: Despite strong evidence of a significant role of MAPK signaling in chronic lymphocytic leukemia (CLL), phosphatase development and progression, this pathway is up to date not targeted in CLL therapy and available BRAF and MEK inhibitors are not efficient in reducing tumor progression. In this study, we evaluated the effects of targeted hyperactivation of the MAPK signaling pathway in CLL.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

DISEASE(S): Chronic Lymphocytic Leukemia

SUBMITTER: Piero Giansanti  

LAB HEAD: Bernhard Kuster

PROVIDER: PXD032039 | Pride | 2023-10-09

REPOSITORIES: Pride

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Dataset's files

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Action DRS
01862_A01_P019415_S00_I00_U01_R1_TMT10.raw Raw
01862_A01_P019415_S00_I00_U01_R2_TMT10.raw Raw
01862_B01_P019415_S00_I00_U02_R1_TMT10.raw Raw
01862_B01_P019415_S00_I00_U02_R2_TMT10.raw Raw
01862_C01_P019415_S00_I00_U03_R1_TMT10.raw Raw
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Publications

Despite available targeted treatments for the disease, drug-resistant chronic lymphocytic leukemia (CLL) poses a clinical challenge. The objective of this study is to examine whether the dual-specific phosphatases DUSP1 and DUSP6 are required to negatively regulate mitogen-activated protein kinases (MAPKs) and thus counterbalance excessive MAPK activity. We show that high expression of DUSP6 in CLL correlates with poor clinical prognosis. Importantly, genetic deletion of the inhibitory phosphata  ...[more]

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