Dataset Information
EXTL3ΔN purification from transgenic HEK
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Embryonic Stem Cell
SUBMITTER: 
Louis Wilson
LAB HEAD: Paul Dupree
PROVIDER: PXD032145 | Pride | 2022-07-12
REPOSITORIES: Pride
Dataset's files
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Publications
The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis.
Nature communications 20220608 1
Heparan sulfate is a highly modified O-linked glycan that performs diverse physiological roles in animal tissues. Though quickly modified, it is initially synthesised as a polysaccharide of alternating β-D-glucuronosyl and N-acetyl-α-D-glucosaminyl residues by exostosins. These enzymes generally possess two glycosyltransferase domains (GT47 and GT64)-each thought to add one type of monosaccharide unit to the backbone. Although previous structures of murine exostosin-like 2 (EXTL2) provide insigh ...[more]
