Proteomics

Dataset Information

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Quantitative Proteomics of Medium-Sized Extracellular Vesicle-Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers


ABSTRACT: Lacunar infarction (LACI), a difficult to diagnose, subtype of acute ischemic stroke affects around 25% of all ischemic stroke cases. Despite having an excellent recovery during acute phase, certain LACI patients have poor mid- to long-term prognosis due to the recurrence of vascular events or dementia. The existing clinical protocols are unable to predict the prognosis of LACI patients. Blood-based biomarkers maybe useful as complementary prognostic and research tools.

INSTRUMENT(S): QSTAR

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet, Blood Plasma

DISEASE(S): Cardiovascular System Disease

SUBMITTER: SoFong Cam Ngan  

LAB HEAD: Newman Sze

PROVIDER: PXD032225 | Pride | 2023-03-11

REPOSITORIES: Pride

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Quantitative Proteomics of Medium-Sized Extracellular Vesicle-Enriched Plasma of Lacunar Infarction for the Discovery of Prognostic Biomarkers.

Datta Arnab A   Chen Christopher C   Gao Yong-Gui YG   Sze Siu Kwan SK  

International journal of molecular sciences 20221001 19


Lacunar infarction (LACI), a subtype of acute ischemic stroke, has poor mid- to long-term prognosis due to recurrent vascular events or incident dementia which is difficult to predict using existing clinical data. Herein, we aim to discover blood-based biomarkers for LACI as a complementary prognostic tool. Convalescent plasma was collected from forty-five patients following a non-disabling LACI along with seventeen matched control subjects. The patients were followed up prospectively for up to  ...[more]

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