Dataset Information

Potential anti-inflammatory effect of inulin in an inflammatory cell model (mouse macrophages with LPS)

ABSTRACT: A potential anti-inflammatory effect of inulin, a fructan found in thousands of plant species, has been described. In this study we look at the effect of inulin, at the proteome level, in a murine cellular model of inflammation. Our interest is focused on describing the molecular mechanisms involved in this possible anti-inflammatory bioactivity.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Macrophage

SUBMITTER: Ignacio Ortea

LAB HEAD: Ignacio Ortea

PROVIDER: PXD032759 | Pride | 2023-03-11

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20210629-02_2021027-IL4_1005.d.zip	Other
	20210629-05_2021027-L2_1008.d.zip	Other
	20210629-06_2021027-HL4_1009.d.zip	Other
	20210629-07_2021027-HL5_1010.d.zip	Other
	20210629-08_2021027-C3_1011.d.zip	Other

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Publications

Exploring the Anti-Inflammatory Effect of Inulin by Integrating Transcriptomic and Proteomic Analyses in a Murine Macrophage Cell Model.

Farabegoli Federica F Santaclara Francisco J FJ Costas Daniel D Alonso Mercedes M Abril Ana G AG Espiñeira Montserrat M Ortea Ignacio I Costas Celina C

Nutrients 20230208 4

Inulin is a natural polysaccharide classified as a soluble fiber with demonstrated prebiotic activity. Prebiotics can reduce intestinal and systemic inflammation through modulation of the gut microflora and their metabolites. Additionally, extensive research is illuminating the role of macrophages in the interaction between gut microbiota and many systemic inflammatory diseases. In this study, the anti-inflammatory properties of inulin were evaluated using a murine macrophage cell model (RAW 264 ...[more]

PMID: 36839217

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