Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human) Spodoptera Frugiperda
TISSUE(S): Cell Suspension Culture
SUBMITTER: Marc Sylvester
LAB HEAD: Ulrich Schweizer
PROVIDER: PXD032784 | Pride | 2022-05-31
REPOSITORIES: Pride
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International journal of molecular sciences 20220511 10
The three isoenzymes of iodothyronine deiodinases (DIO1-3) are membrane-anchored homo-dimeric selenoproteins which share the thioredoxin-fold structure. Several questions regarding their catalytic mechanisms still remain open. Here, we addressed the roles of several cysteines which are conserved among deiodinase isoenzymes and asked whether they may contribute to dimerization and reduction of the oxidized enzyme with physiological reductants. We also asked whether amino acids previously identifi ...[more]