Proteomics

Dataset Information

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Proteomic analysis of mouse liver with conditional knock-out of Cathepsin D in macrophages


ABSTRACT: The cell-specific role of lysosomal protease cathepsin D (CtsD) in liver fibrosis is not completely clear. This study reports that while CtsD is highly expressed in liver macrophages of cirrhotic patients, CtsD deletion in macrophages resulted in enhanced liver fibrosis. For this scope, a macrophage-CtsD knock-out mouse (CtsDMac) model was generated. Livers obtained from the mouse model and from its control were analyzed by shotgun label-free quantitative (LFQ) proteomics.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver, Cell Culture

SUBMITTER: Michele Costanzo  

LAB HEAD: Michele Costanzo

PROVIDER: PXD032827 | Pride | 2024-07-25

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
CtsD_CTRL1.raw Raw
CtsD_CTRL10.raw Raw
CtsD_CTRL11.raw Raw
CtsD_CTRL12.raw Raw
CtsD_CTRL2.raw Raw
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