Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Embryonic Stem Cell
SUBMITTER: Tian Zhang
LAB HEAD: Steven Gygi
PROVIDER: PXD033001 | Pride | 2023-05-10
REPOSITORIES: Pride
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TMT10_1.raw | Raw | |||
TMT10_10.mzIdentML | Mzid | |||
TMT10_10.raw | Raw | |||
TMT10_11.mzIdentML | Mzid |
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Cell genomics 20230323 4
Genetic background drives phenotypic variability in pluripotent stem cells (PSCs). Most studies to date have used transcript abundance as the primary molecular readout of cell state in PSCs. We performed a comprehensive proteogenomics analysis of 190 genetically diverse mouse embryonic stem cell (mESC) lines. The quantitative proteome is highly variable across lines, and we identified pluripotency-associated pathways that were differentially activated in the proteomics data that were not evident ...[more]