Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Christopher Ebmeier
LAB HEAD: Professor Tatiana Kutateladze
PROVIDER: PXD033397 | Pride | 2022-08-12
REPOSITORIES: Pride
Items per page: 1 - 5 of 13 |
Nature communications 20220608 1
The assembly and function of the yeast general transcription factor TFIID complex requires specific contacts between its Taf14 and Taf2 subunits, however, the mechanism underlying these contacts remains unclear. Here, we determined the molecular and structural basis by which the YEATS and ET domains of Taf14 bind to the C-terminal tail of Taf2 and identified a unique DNA-binding activity of the linker region connecting the two domains. We show that in the absence of ligands the linker region of ...[more]